Difference between Penicillin and Amoxicillin
Difference between Penicillin and Amoxicillin

Difference between Penicillin and Amoxicillin

Penicillin and amoxicillin are both known as antibiotics, exacerbates that upset and demolish bacteria. Penicillin is the antecedent to amoxicillin, and both anti-toxins are gotten from a mold called Penicillium glaucum. The disclosure of penicillin’s impact on bacteria prompted an upheaval in therapeutic treatment and the improvement of many different antibiotics, including amoxicillin.


Penicillin is a gathering of anti-infection agents which incorporate penicillin G, penicillin V, procaine penicillin and benzathine penicillin. Penicillin anti-toxins were included in the first medicines to be viable against numerous bacterial diseases brought about by staphylococci and streptococci.


Amoxicillin, additionally spelled amoxycillin, is an anti-toxin valuable for treatment of bacterial infections. It is the principal line treatment for ear diseases. It might likewise be utilized for strep throat, skin diseases, pneumonia and urinary tract contaminations among others. It is mostly used as oral medicines.

Penicillin VS Amoxicillin

In this article we are going to discuss the differences between both these antibiotics.

  • Based:

Penicillin is the antibiotic which depends on Penicillium glaucum mold which assaults cell wall composition of bacteria.

Amoxicillin is the antibiotic which is depends on penicillin that assaults cell wall composition of bacteria.

  • Gram positive bacteria:

There is restricted amount of gram positive bacteria in penicillin.

There is more extensive scope of gram-positive bacteria in amoxicillin as compare to penicillin.

  • Allergic reaction:

Penicillin will lead to less allergic reaction as compare to amoxicillin.

Amoxicillin will lead to allergic reaction and more reaction as compare to penicillin.

  • Benefits:

Penicillin is best against ions related to soft tissues and strep, meningitis, syphilis and pneumonia.

Amoxicillin is successful against the greater part of the identical strains as the penicillin, yet is more compelling against otitis media which is ear infection, endocarditis that is heart valve diseases, and different infections brought on by enteroccocus strains.

  • Cost:

Penicillin is an antibiotic which is expensive as compared to amoxicillin. As indicated by GoodRx.com, Penicillin that contains 40 pills of 500 mg extents in cost from $10.00-$37.20.

Amoxicillin is impressively less expensive than penicillin, however neither one of the antibiotics is exceptionally costly. As indicated by GoodRx.com, Amoxil, which contains 30 pills of 500 mg of brand name amoxicillin usually extents in cost from $4.00-$12.79.

  • Drug class:

Amoxicillin belongs to the drug class known as Aminopenicillin antibiotic.

Penicillin belongs to the drug class known as Natural penicillin anti-toxins.

  • Metabolism:

The half life of antibiotic named as penicillin is roughly an hour or half hour. It does not experience critical digestion system in human body. The vast majority of the penicillin stays in unaltered shape and is discharged in unchanged state.

The half life of antibiotic named as amoxicillin is roughly an hour. Amoxicillin does not experience broad digestion system and is discharged in pee in unaltered structure.

  • Elimination:

The fundamental course of discharge of penicillin is in the course of glomerular filtration and additionally tubular arrangement of kidneys.

The fundamental course of discharge of amoxicillin is through the urine. Little measure of medication is likewise discharged in feces and bile.


From the above article we conclude that penicillin is less allergic but expensive as compare to amoxicillin but it totally depends on doctor’s prescription that which one is better.