Difference between Penicillin and Amoxicillin

Penicillin and amoxicillin are both known as antibiotics, exacerbates that upset and demolish bacteria. Penicillin is the antecedent to amoxicillin, and both anti-toxins are gotten from a mold called Penicillium glaucum. The disclosure of penicillin’s impact on bacteria prompted an upheaval in therapeutic treatment and the improvement of many different antibiotics, including amoxicillin. Neither amoxicillin nor penicillin can work to treat virus-caused illnesses such as colds or flu.

Penicillin

Penicillin is a gathering of anti-infection agents which incorporate penicillin G, penicillin V, procaine penicillin and benzathine penicillin. Penicillin anti-toxins were included in the first medicines to be viable against numerous bacterial diseases brought about by staphylococci and streptococci.

 Amoxicillin

Amoxicillin, additionally spelled Amoxycillin, is an anti-toxin valuable for treatment of bacterial infections. It is the first line treatment for ear diseases. It might likewise be utilized for strep throat, skin diseases, pneumonia and urinary tract contaminations, among others. It is mostly used as oral medicines.

Penicillin VS Amoxicillin

In this article, we are going to discuss the differences between both these antibiotics.

• Based:

Penicillin is the antibiotic which depends on Penicillium glaucum mold which assaults cell wall composition of bacteria.

Amoxicillin is the antibiotic which depends on penicillin that assaults cell wall composition of bacteria.

• Gram positive bacteria:

There is reduced amount of gram-positive bacteria in penicillin.

There is a more extensive scope of gram-positive bacteria in amoxicillin as compare to penicillin.

• Allergic reaction:

Penicillin will lead to the less allergic reaction as compared to amoxicillin. Allergy to that of the penicillin involves hives, rash and itching. Extreme results include anaphylaxis, a life-threatening disease incorporating several processes in the body.

Amoxicillin will lead to an allergic reaction and more reaction as compared to penicillin. A maculopapular rash typically occurs around 3 to 10 days after a person takes the medication first, but it can happen at any time. .A severe reaction includes swelling of face, tongue and throat along with dizziness and breathing problem.

Benefits:

Penicillin is best against ions related to soft tissues and strep, meningitis, syphilis and pneumonia.

Amoxicillin is successful against the more significant part of the identical strains as the penicillin, yet is more compelling against otitis media which is an ear infection, endocarditis that is heart valve diseases, and different infections brought on by Enterococcus strains.

• Cost:

Penicillin is an antibiotic which is expensive as compared to amoxicillin as indicated by GoodRx.com, Penicillin that contains 40 pills of 500 mg extents in cost from $10.00-$37.20.

Amoxicillin is impressively less expensive than penicillin. However, neither one of the antibiotics is exceptionally costly. As indicated by GoodRx.com, Amoxil, which contains 30 pills of 500 mg of brand name amoxicillin usually extents in cost from $4.00-$12.79.

• Drug class:

Amoxicillin belongs to the drug class known as Aminopenicillin antibiotic.

Penicillin belongs to the drug class known as Natural penicillin anti-toxins.

• Metabolism:

The half-life of antibiotic named as penicillin is roughly an hour or half-hour. It does not experience critical digestion system in the human body. The vast majority of the penicillin stays in unaltered shape and is discharged in stable state.

The half-life of antibiotic named as amoxicillin is roughly an hour. Amoxicillin does not experience extensive digestion system and is discharged in pee in unaltered structure.

• Elimination:

The fundamental course of discharge of penicillin is in the course of glomerular filtration and additionally tubular arrangement of kidneys.

The fundamental course of discharge of amoxicillin is through the urine. A little measure of medication is likewise discharged in faeces and bile.

Side-Effects:  

Common side effects seen with penicillin and amoxicillin are:

• Nausea and vomiting 
• Fever with chills 
• Headache
• Upset stomach 
• Diarrhea
• Rash
• Swollen, black or hairy tongue.

Less common side effects include:

• Breathing problems
• Dizziness
• Vaginal discharge or itching
• Jaundice
• Seizures

• Drug interaction:

Amoxicillin and penicillin interact with related medicines, too. An effect is when a substance alters how a drug works. That can be harmful or prevent the medication from functioning well. Some of the examples of drugs which most often interact with amoxicillin and penicillin are Methotrexate (anti-cancerous), Warfarin (anti-coagulant), Birth control pills and Probenecid (increases uric acid excretion in urine).

Conclusion

From the above article, we conclude that penicillin is less allergic but expensive as compared to amoxicillin. Still, it depends on the doctor’s prescription, which completely depends upon the nature and severity of the disease.

https://www.healthline.com/health/side-effects-amoxicillin-amoxil-trimox#1

https://www.medicalnewstoday.com/articles/322466

https://www.webmd.com/drugs/2/drug-1531-3295/amoxicillin-oral/amoxicillin-oral/details